Edward Balish, Ph.D. Professor Emeritus, Medical Microbiology and Immunology Professor Emeritus, Department of Surgery 436 Medical Sciences Center 1300 University Avenue Madison, WI 53706-1532 (608) 263-1670 Fax: (608) 265-3461 Dr. Balish can be reached directly at: Dept.of Microbiology and Immunology Medical University of South Carolina 173 Ashley Ave., 535 BSB P.O. BOX 250504 Charleston, SC 29425 (843) 792-6317 Fax: (843) 792-2464 balish@musc.edu

Research Interest:

General Medical Microbiology: gnotobiology; microbial etiology of inflammatory bowel disease (IBD); gastrointestinal ecology and anaerobic microbiology; and immunity to candidiasis

Training:

1957 - B.S., University of Scranton, Scranton, PA
1959 - M.S., University of Syracuse, Syracuse, NY
1963 - Ph.D.,University of Syracuse, Syracuse, NY
1966 - Postdoctoral Fellowship, Atomic Energy Commission Argonne National Lab., Argonne, IL

Publications: NCBI PubMed search for "E. Balish"

Jones-Carson, J., F.A. Vazquez-Torres, and E. Balish. 1997. B cell-independent selection of memory T cells after mucosal immunization with Candida albicans. J. Immunol. 158(9):4328-4335.

Vazquez-Torres, A., and E. Balish. 1997. Macrophages in resistance to candidiasis. [Review] Microbiol. Mol. Biol. Revs. 61(2):170-192.

Uehling, D.T., W.J. Hopkins, E. Balish, Y. Xing, and D.M. Heisey. 1997. Vaginal mucosal immunization for recurrent urinary tract infection: Phase II clinical trial. J. Urol. 157:2049-2052.

Wagner, R.D., T. Warner, L. Roberts, J. Farmer, and E. Balish. 1997. Colonization of congenitally immunodeficient mice with probiotic bacteria. Infect. Immun. 65(8):3345-3351.

Wagner, R.D., C. Pierson, T. Warner, M. Dohnalek, J. Farmer, L. Roberts, M. Hilty, and E. Balish. 1997. Biotherapeutic effects of probiotic bacteria on candidiasis in immunodeficient mice. Infect. Immun. 65(10):4165-4172.

Sundstrom, P., J. Jensen, and E. Balish. 1997. Immune responses to Candida albicans enolase and its utility as a protective antigen, p. 279-287. In: VandenBossche, H., D.A. Stevens, and F.C. Odds (Eds.), Host-Fungus Interplay. Proc. of the 5th Symposium on Topics in Mycology: Host-Fungus Interplay, Stanford, CA (June 27-30, 1995). Natl. Foundation for Infectious Diseases, Bethesda, MD.

Balish, E. and R.D. Wagner. 1998. Probiotic bacteria for prophylaxis and therapy of candidiasis. Revista Iberoamericana de Micologia. 15(4):261-264.

Balish, E., R.D. Wagner, A. Vazquez-Torres, C. Pierson, and T. Warner. 1998. Candidiasis in interferon-g knockout (IFN-g^-/-) mice. J. Infect. Dis. 178(2):478-487.

Hopkins, W.J., A. Gendron-Fitzpatrick, E. Balish, and D.T. Uehling. 1998. Time course and host responses to Escherichia coli urinary tract infection in genetically distinct mouse strains. Infect. Immun. 66(6):2798-2802.

Sellon, R.K., S. Tonkonogy, M. Schultz, L.A. Dieleman, W. Grenther, E. Balish, D.M. Rennick, and R.B. Sartor. 1998. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect. Immun. 66(11):5224-5231.

Wagner, R.D. and E. Balish. 1998. Potential hazards of probiotic bacteria for immunodeficient patients. Bull. Inst. Pasteur. 96(3):165-170.

Wagner, R.D., T. Warner, C. Pierson, L. Roberts, J. Farmer, M. Dohnalek, M. Hilty, and E. Balish. 1998. Biotherapeutic effects of Bifidobacterium spp. on orogastric and systemic candidiasis in immunodeficient mice. Revista Iberoamericana de Micologia. 15(4):265-270.

Wagner, R.D., T. Warner, C. Pierson, L. Roberts, J. Farmer, M. Dohnalek, M. Hilty, and E. Balish. 1998. Variable biotherapeutic effects of Lactobacillus acidophilus isolates on orogastric and systemic candidiasis in immunodeficient mice. Revista Iberoamericana de Micologia. 15(4):271-276.

Balish, E., R.D. Wagner, A. Vazquez-Torres, J. Jones-Carson, C. Pierson, and T. Warner. 1999. Mucosal and systemic candidiasis in IL-8Rh^-/- BALB/c mice. J. Leukoc. Biol. 66(1):144-150.

Jones-Carson, J., E. Balish, and D.T. Uehling. 1999. Susceptibility of immunodeficient gene-knockout mice to urinary tract infection. J. Urol. 161(1):338-341.

Maldonado, M.A., V. Kakkanaiah, G.C. MacDonald, F. Chen, E.A. Reap, E. Balish, W.R. Farkas, J.C. Jennette, M.P. Madaio, B.L. Kotzin, P.L. Cohen, and R.A. Eisenberg. 1999. The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice. J. Immunol. 162(11):6322-6330.

Schultz, M. S.L. Tonkonogy, R.K.Sellon, C. Veltkamp, V.L. Godfrey, J. Kwon, W.B. Grenther, E. Balish, I. Horak, and R.B. Sartor. 1999. IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation. Am. J. Physiol. 39(6):G1461-G1472.

Song, F., K. Ito, T.L. Denning, D. Kuninger, J. Papaconstantinou, W. Gourley, G. Klimpel, E. Balish, J. Hokanson, and P.B. Ernst. 1999. Expression of the neutrophil chemokine KC in the colon of mice with enterocolitis and by intestinal epithelial cell lines: Effects of flora and proinflammatory cytokines. J. Immunol. 162(4):2275-2280.

Vazquez-Torres, A., J. Jones-Carson, R.D. Wagner, T. Warner, and E. Balish. 1999. Early resistance of interleukin-10 knockout mice to acute systemic candidiasis. Infect. Immun. 67(2):670-674.

Wagner, R.D., C. Pierson, T. Warner, M. Dohnalek, M. Hilty, and E. Balish. 2000. Probiotic effects of feeding heat-killed Lactobacillus acidophilus and Lactobacillus casei to Candida albicans-colonized immunodeficient mice. J. Food Prot. 63(5):638-644.

Jones-Carson, J, A Vazquez-Torres, T Warner, E Balish. 2000. Disparate requirement for T cells in resistance to mucosal and acute systemic candidiasis. Infect Immun 68(4):2363-2365.

Park, S.-H., K. Benlagha, D. Lee, E. Balish, E, A. Bendelac. 2000. Unaltered phenotype, tissue distribution and function of Va14⁺ NKT cells in germ-free mice. Eur. J. Immunol. 30:620-625.

Kawachi S., S. Jennings, J. Panes, A. Cockrell, F.S. Laroux, L. Gray, M. Perry, H. Van der Heyde, E. Balish, D.N. Granger, and R.A. Specian. 2000. Cytokine and endothelial cell adhesion molecule expression in interleukin-10-deficient mice. Am. J. Physiol. Gastrointest. Liver Physiol. 278(5):G734-G743.

Wagner, R.D., M. Dohnalek, M. Hilty, A. Vazquez-Torres, and E. Balish. 2000. Effects of probiotic bacteria on humoral immunity to Candida albicans in immunodeficient bg/bg-nu/nu and bg/bg-nu/+ mice. Rev. Iberoam. Micol. 17(2):55-59.

Dieleman, L.A., A. Arends, S.L. Tonkonogy, D.W. Craft, W. Grenther, R.K. Sellon, E. Balish, and R.B. Sartor. 2000. Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10 deficient mice. Infect. Immun. 68(9):5107-5113.

Veltkamp, C., S.L. Tonkonogy, Y.P. de Jong, C. Albright, W.B. Grenther, E. Balish, C. Terhorst, and R.B. Sartor. 2001. Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tge26. Gastroenterology 120(4):900-913.

Balish, E., T. Warner, C.J. Pierson, D.M. Bock, and R.D. Wagner. 2001. Oroesophageal candidiasis is lethal for transgenic mice with combined natural killer and T cell defects. Med. Mycol. 39(3):261-268.

Sundstrom, P., E. Balish, and C. Allen. 2001. Essential role of the Candida albicans transglutaminase substrate, HWP1, in lethal oroesophageal candidiasis in transgenic mice with combined NK and T-cell defects. J. Infect. Dis. (Submitted).