Richard A. Proctor, M.D. Professor Emeritus, Medical Microbiology and Immunology Professor Emeritus, Department of Medicine rap@wisc.edu

Research Interest

Bacterial pathogenesis: Defining host-bacterial interactions at cellular and molecular levels. Clone and characterize S. aureus genes involved in electron transport and signaling that controls toxin production. Define molecular and biochemical pathways of endotoxin activation of macrophages; inhibition of endotoxin activity by adenine nucleotide derivatives.

Training

1966, University of Michigan, Ann Arbor, MI
1970, M.D., University of Michigan, Ann Arbor, MI
1970 - 71, Internship, University of Wisconsin-Madison, Madison, WI
1974 - 76, Internal Medicine Residency: Georgetown University, Washington, DC
1976 - 78, Infectious Diseases Post-Doctoral Fellow: University of Wisconsin-Madison, Madison, WI

Publications – NCBI PubMed search for "R.A. Proctor"

Jonsson, I-M, C von Eiff, RA Proctor, G Peters, C Ryden, and A Tarkowski.  Virulence of a hemB mutant Staphylococcus aureus small colony variant in a murine model of septic arthritis.  Microbial Pathog 34: 73-79, 2003.

Bates, D, C von Eiff, G Peters, A Bayer, and RA Proctor.  A menD, but not hemB, mutant persists within the kidney in the rabbit endocarditis model. J Infect Dis. 187: 1654-1661, 2003.

Kahl B, A Duebbers, G Lubritz, J Haeberle, HG Koch, B Ritzerfeld, M Reilly, E Harms, RA Proctor, M Herrmann, and G Peters. Population dynamics and persistence of Staphylococcus aureus infection in cystic fibrosis patients. J Clin Microbiol.41: 4424 – 4427, 2003.

Kohler C, C von Eiff, G Peters, RA Proctor, M Hecker, and S Engelmann.  Physiological characterization of a heme-deficient mutant of Staphylococcus aureus by a proteomic approach.  J Bacteriol 185: 6928 – 6937, 2003.

Bauer SM, Santschi EM, Fialkowski J, Clayton MK, Proctor RA.  Quantification of Staphylococcus aureus adhesion to equine bone surfaces passivated with Plasmalyte^TM and hyperimmune plasma.  Vet Surg. 33: 376-381, 2004.

Vuong C, Kidder JB, Jacobson ER, Otto M, Proctor RA, Somerville GA. Staphylococcus epidermidis polysaccharide intercellular adhesin production significantly increases during tricarboxylic acid cycle stress. J Bacteriol. 187: 2967-2973, 2005.

Chatterjee, I, Becker P, Grundmeier M, Bischoff M, Somerville GA, Peters G, Sinha B, Proctor RA, and Herrmann M.  Staphylococcus aureus ClpC is required for stress resistance, aconitase activity, growth recovery, and death.   J Bacteriology 187: 4488-4496, 2005.

Kipp F, BC Kahl, K Becker, EJ Baron, RA Proctor, G Peters, and C von Eiff.  Evaluation of two chromogenic agar media for recovery and identification of Staphylococcus aureus small colony variants  J. Clin. Microbiol. 43: 1956-1959, 2005.

Samuelsen, Ø, Haukland, HH, Kahl, B, von Eiff, C, Proctor, RA, Ulvatne, H, Sandvik, K, Vorland, LH.  Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin B.  J Antimicrobial Chemother 56: 1126-1129, 2005.

Bayer AS, McNamara P, Yeaman MR, Lucindo N, Jones T, Cheung AL, Sahl HG, Proctor RA. Transposon disruption of the complex I NADH oxidoreductase gene (snoD) in Staphylococcus aureus is associated with reduced susceptibility to the microbicidal activity of thrombin-induced platelet microbicidal protein 1.   J Bacteriol. 188: 211-222, 2006.

von Eiff C, McNamara P, Becker K, Bates D, Lei XH, Ziman M, Bochner BR, Peters G, Proctor RA.  Phenotype microarray profiling of Staphylococcus aureus menD and hemB mutants with the small-colony-variant phenotype.  J Bacteriol. 188: 687-693, 2006.

Proctor RA, von Eiff C, Kahl BC, Becker K, McNamara P, Herrmann M, and Peters G. Small colony variants: A pathogenic form of bacteria that facilitates persistent and recurrent infections.  Nature Microbiol Rev 4: 295-305, 2006.

Becker, K, N Al Laham, W Fegeler, R Proctor, G Peters, C von Eiff.  Fourier-transform infrared spectroscopic analysis is a powerful tool for studying the dynamic changes in Staphylococcus aureus small colony variants.  J Clin Microbiol.  44: 3274-3278, 2006.

Seggewiß, J, Becker K, Kotte O, Eisenacher M, Yazdi MRK, Fischer A, McNamara P, Proctor, RA, Peters G, Heinemann M, and von Eiff C. Reporter metabolite analysis of transcriptional profile of a Staphylococcus aureus strain with normal phenotype and its isogenic hemB mutant display in the small colony variant phenotype. J Bact 188: 7765-7777, 2006.

Proctor, RA, C von Eiff, BC Kahl, K Becker, P McNamara, M Herrmann, and G Peters. Small colony variants: A pathogenic form of bacteria that facilitates persistent and recurrent infections.  Nature Microbiol Rev 4: 295-305, 2006.

Mukhopadhyay, K, W Whitmire, YQ Xiong, J Molden, A Peschel, P Staubitz, J Adler-Moore, P.J McNamara, RA Proctor, MR Yeaman, and AS Bayer.  In vitro susceptibility of Staphylococcus aureus to thrombin-induced platelet microbicidal protein-1 (tPMP-1) is influenced by cell membrane phospholipid composition and phospholipid asymmetry.   Microbiol 153: 1187-1197, 2007.

Chatterjee I, M Herrmann, R.A. Proctor, G. Peters, B. C. Kahl. Enhanced post-stationary phase survival of a clinical thymidine-dependent small colony variant of Staphylococcus aureus results from a lack of functional tricarboxylic cycle. J Bact 189:2936-2940, 2007.

Al Laham, N, H Rohde, G Sander, A Fischer, M Hussain, C Heilmann, D Mack R Proctor, G Peters, K Becker, and C von Eiff.  Augmented expression of polysaccharide intercellular adhesin in a defined Staphylococcus epidermidis mutant with small colony variant phenotype.  J Bacteriol. 189: 4494-4501, 2007.

Chatterjee I, Kriegeskorte A, Fischer A, Deiwick S, Theimann N, Proctor RA, Peters G, Herrmann M, Kahl BC. In vivo mutations of thymidylate synthase (thyA) are responsible for thymidine-dependency in clinical small colony variants (TD-SCVs) of Staphylococcus aureus.  J Bacteriol. 2007 Sep 28; [Epub ahead of print]