Dr. Rodney A. Welch

Lab information

Research Interest

Microbiology - Bacterial pathogenesis; molecular genetics; protein secretion; and structure/function of bacterial toxins.

Training

1974 - B.S., Cornell University, Ithaca, NY
1979 - Ph.D., Medical College of Virginia, Richmond, VA
1980-81 - Postdoctoral fellowship, University of Washington, Seattle, WA
1981-82 - Postdoctoral fellowship, Stanford University, Stanford, CA

Publications – NCBI PubMed search for "R.A. Welch" – Download PDF's

Szabady, R. L., M. A. Lokuta, K. B. Walters, A. Huttenlocher and R. A. Welch. 2009. Modulation of Neutrophil Function by a Secreted Mucinase of Escherichia coli O157:H7. PloS Pathog. 5:e100032093.

Anfora, A. T., D. K. Hallidin, B. J. Haugen and R. A. Welch. 2008. Uropathogenic Escherichia coli CFT073 is Adapted to Acetatogenic Growth but Does Not require Acetate during Murine Urinary Tract Infection. Infect. Immun. 76:5760-5767.

Anfora A. T., B. J. Haugen, P. Roesch, P. Redford and R. A. Welch. 2007. Roles of Serine Accumulation and Catabolism in the Colonization of the Murine Urinary Tract by Escherichia coli CFT073. Infect. Immun. 75:5298-5304.

Månsson, L. E., P. Kjäll, S. Pellett, G. Nagy, R. A. Welch, F. Bäckhed, T. Frisan, and A. Richter-Dahlfors. 2007. Role of the Lipopolysaccharide-CD14 Complex for the Activity of Hemolysin from Uropathogenic Escherichia coli. Infect. Immun. 75:997-1004.

Haugen, B. J., S. Pellett, P. Redford, H. L. Hamilton, P. L. Roesch and R. A. Welch. 2007. In vivo gene expression analysis identifies genes required for enhanced colonization of the mouse urinary tract by uropathogenic Escherichia coli strain CFT073 dsdA. Infect Immun. 75:278-289.

Moritz, R. and R. A. Welch. 2006. The Escherichia coli argW-dsdCXA Genetic Island is Highly Variable and E. coli K1 Strains commonly possess two copies of dsdCXA. J Clin Microbiol. 44:4038-4048.

Anfora, A. T. and R. A. Welch. 2006. DsdX Is the Second D-Serine Transporter in Uropathogenic Escherichia coli Clinical Isolate CFT073. J. Bacteriol. 188:6622–6628.

Grys, T. E., L. Walters and R. A. Welch. 2006. Characterization of the StcE Protease Activity of Escherichia coli O157:H7. J Bacteriol. 188:4646-4653.

Redford, P. and R. A. Welch. 2006. Role of Sigma E-Regulated Genes in Escherichia coli Uropathogenesis. Infect. Immun. 74:4030-4038.

Bryan, A., P. Roesch, L. Davis, R. Moritz, S. Pellett and R. A. Welch. 2006. Regulation of type 1 fimbriae by unlinked FimB- and FimE-like recombinases in uropathogenic E. coli strain CFT073. Infect. Immun. 74:1072-1083.

Welch, R.A. 2005. RTX Hemolysins of Escherichia coli. In Escherichia coli and Salmonella, Cellular and Molecular Biology. ASM Press, Washington, D.C.

Snyder, J.A. B. J. Haugen, C. V. Lockatell, N. Maroncle, E. C. Hagan, D. E. Johnson, R. A. Welch and H. L. T. Mobley. 2005. Escherichia coli type 1 fimbrial inverse regulation of P fimbriae and significance during urinary tract infection. Infect. Immun.. 73:7588-7596.

Grys, T. E., M. B. Siegel, W. W. Lathem, and R. A. Welch. 2005. The StcE Protease Contributes to Intimate Adherence of Enterohemorrhagic Escherichia coli O157:H7 to Host Cells. Infect. Immun. 73:1295-303.

Ravindran, S., T. E. Grys, R. A. Welch, M. Schapira, and P. A. Patston. 2004. Inhibition of Plasma Kallikrein by C1-Inhibitor: Role of Endothelial Cells and the Amino-Terminal Domain of C1-inhibitor. Thrombosis and Haemostasis. 92:1277-83.

Snyder, J. A., B. J. Haugen, E. Buckles, C. V. Lockatell, D. E. Johnson, M. S. Donnenberg, R. A. Welch and H. L. Mobley. 2004. The Transcriptome of Uropathogenic Escherichia coli During Urinary Tract Infection. Infect. Immun. 72:6373-6381.

Lathem, W., T. Bergsbaken and R. A. Welch. 2004. Potentiation of C1 esterase inhibitor by StcE, a metalloprotease secreted by Escherichia coli O157:H7. J Exp Med. 199:1077-1087.

Roesch, P., P. Redford, S. Batchelett, R. Moritz, S. Pellett, B. Haugen, F. Blattner, and R. A. Welch. 2003. Uropathogenic Escherichia coli use D-serine deaminase to modulate infection of the murine urinary tract. Molecular Microbiology. 49:55-67.

Lathem, W.,T. Bergsbakken,S. Witowski, N. T, Perna and R. A. Welch. 2003. Acquisition of stcE, a C1 esterase inhibitor-specific metalloprotease, during the evolution ofEscherichia coli O157:H7. J. Infect. Dis. 187:1907-1914.

Redford, P., P. Roesch, and R. Welch. 2003. degS, an antirepressor of sigmaE, is necessary for virulence and is among extraintestinal Escherichia coli genes induced in murine peritonitis. Infection and Immunity. Infect. Immun. 68:6179-6185.

Welch, R.A., V. Burland, G. Plunkett III, P. Redford, P. Roesch, D. Rasco, S.R. Liou, A. Boutin, J. Hackett, D. Stroud, G. Mayhew, D. Rose, Shiguo Zhou, David Schwartz, N.T. Perna, H.L. Mobley, M. Donnenberg, F.R. Blattner. 2002. Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli. Proc. Natl. Acad. Sci. (USA) 99:17020-17024.

Redford, Peter. Rodney A. Welch. 2002. Extraintestinal Escherichia coli as a Model System for the Study of Pathogenicity Islands. Current Topics in Microbiology and Immunology. 264:15-30.

Lathem, W., T. Grys, S. Witowski, A. Torres, J. Kaper, P. Tarr and R. Welch. 2002. StcE, a metalloprotease secreted by Escherichia coli O157:H7, specifically cleaves C1-esterase inhibitor. Molecular Microbiology. 45:277-288.

Heimer, Susan, Rodney A. Welch, Nicole Perna, Gyorgi Posfai, Peter Evans, James B. Kaper, Fred R. Blattner, and Harry, L. T. Mobley. 2002. Urease of Enterohemorrhagic E. coli: Evidence for Regulation by Fur and a Trans-Acting Factor. Infect. Immun. 70:1027-1031.