MMI 720: Topics in Immunology

MMI 720 Topics in Immunology - Fall 2007

Director: Jenny Gumperz, Ph.D., Room 4157 Microbial Sciences Building, 263-6902, jegumperz@wisc.edu

Date/Time: Tuesday & Thursday, 4:00 – 5:15 PM

Location: Room 1510 Microbial Sciences Building, 1550 Linden Drive

Prequisites: MMI/Ahabs/Bact 528 or equiv.

Credits: 3

Catalogue Description: Advanced course with lecture-discussion format. Cellular and molecular mechanisms of regulation of the immune response.

Date	Description	Speaker
Week 1	Course Introduction
Sept 4	Introduction to the course, etc. Course Overview (Word Document; click here for PDF) Syllubus (Word Document; click here for PDF) Student Presentation Topics (Word Document; click here for PDF) First assignment (Word Document; click here for PDF)
Sept 6	Discussion of first assignment (Word Document; click here for PDF).
Week 2	Immune responses to Immunodeficiency Virus infection
Sept 11	Discussion of papers: Gaduin et al JEM 2006 Wherry et al Nat Imm 2003 Koff et al NI rev 2006
Sept 13	"AIDS Vaccine Development."	Dr. David Watkins UW Dept. Pathology and Lab Medicine
Week 3	T regulatory cells
Sept 18	Discussion of papers: Marangoni et al JEM 2007 Tang et al NI 2005 von Boehmer NI rev 2005
Sept 20	"Immune Homeostasis and the implications of GRAIL in CD25 T regulatory cell biological function."	Dr. Christine Seroogy UW Dept. Pediatrics, seminar
Week 4	Neutrophils
Sept 25	Discuss papers: Keizer-Gunnink JCB 2007 Mathias et al JLB 2006 Van Haastert+Devreotes Rev 2004
Sept 27	"Retrograde chemotaxis of neutrophils: signaling backwards?"	Dr. Anna Huttenlocher UW Depts. Pediatrics and MMI
Week 5	Invertebrate immune mechanisms
Oct 2	Discuss papers (led by Dr. Chris Seroogy): Lupp et al CH+M 2007 Rakoff-Nahoum Cell 2004 Cheesman+Guillemin rev Rawls comment
Oct 4	"Animal-microbe partnerships and their interface with the immune system."	Dr. Margaret McFall-Ngai UW Dept. MMI
Week 6	NK cells
Oct 9	Discussion of papers: Tayade et al JI 2007 Hanna et al Nat Med 2006 leBouteiller N+V Nat 2006 Freud+Caligiuri Imm rev
Oct 11	"NK cell phenotype and function in ovarian cancer and human pregnancy."	Dr. Manish Patankar UW Dept. Obstetrics and Gynecology
Week 7	Various Topics
Oct 16	Student Presentations I
Oct 18	Student Presentations II
Week 8	Immune response to Epstein-Barr Virus
Oct 23	Discussion of papers: Adihikary et al JEM 2006 Bickham et al 2003 Heller+Munz JEM 2006 commt Moss et al review
Oct 25	"EBV interactions with the host immune response: pros and cons."	Dr. Shannon Kenney UW Depts. Medicine and Oncology
Week 9	Asthma
Oct 30	Discussion of papers: Ling et al Lancet 2004 Liu et al JEM 2006 Zhang-Hoover et al JI 2005 Kuipers+Lambrecht rev 2004
Nov 1	"Regulatory T cells in asthma."	Dr. Jim Gern UW Dept. Pediatrics
Week 10	gd TCR structural biology and recognition
Nov 6	Discuss papers: Adams et al Science 2005 Borg et al Nature 2007 Garcia+Adams Cell rev 2005 Morita et al Immunity 1995
Nov 8	"Molecular recognition principles of gamma delta T cell receptors."	Dr. Erin Adams University of Chicago Dept. Biochemistry and Molecular Biology
Week 11	Maternal-fetal immunology
Nov 13	Discuss papers: Hiby JEM 2004 Vernochet BiolReprod 2005 Moffett+Loke rev 2006 Golos HI rev 2003
Nov 15	"Placental MHC class I molecules: maternal-fetal immune tolerance and beyond?"	Dr. Ted Golos UW Dept. Obstetrics and Gynecology
Week 12	Various Topics
Nov 20	Student Presentations III
Nov 22	No class (Thanksgiving)
Week 13	Immune responses to fungal infections
Nov 27	Discuss papers: Gut-Landmann et al NI 2007 Rivera et al Immunity 2006 Brown rev Nat Imm 2006
Nov 29	"Selective pathways to fungal recognition and immunity."	Dr. Bruce Klein UW Depts. Pediatrics and MMI
Week 14	Src kinases in T cell differentiation
Dec 4	Discuss papers: Cannons et al Immunity 2004 Nichols et al SAP NKT NI 2005 Veillette SAP rev Godfrey NKT rev
Dec 6	"Tyrosine kinase pathways directing effector T cell development and function."	Dr. Paul Stein Northwestern University Depts. Dermatology and Microbiology and Immunology
Week 15	Various Topics
Dec 11	Student Presentations IV
Dec 13	Wrap-up, etc.