MMI 740 - Mechanism of Microbial Pathogenesis

Director: Joe Dillard, Rm 6301 Microbial Sciences Bldg, 265-2837, jpdillard@wisc.edu

Date / Time: Tuesday & Thursday, 9:00 – 10:15 AM

Location: Rm 1510 Microbial Sciences Building (1550 Linden Drive)

Prequisites: Cons inst, MM&I 301 or equiv & a course in immunology

Credits: 3

Catalogue Description: Lecture-discussion. Host-pathogen (bacterial pathogens) relationships in microbial diseases.

Schedule for Fall 2008
(Download as: Word Doc or PDF)

Week	Date	Topic	Lecturer
1	Sept 2	Bacterium-Host Interactions	Dillard
	Sept 4	Pathogens & Pathogenic Factors	Dillard

2	Sept 9	No class
	Sept 11	Host Responses	Paulnock

3	Sept 16	Techniques in Pathogenesis Research	Dillard
	Sept 18	Writing Your Grant	Dillard

4	Sept 23	Symbiosis	McFall-Ngai
	Sept 25	Discussion Host Transmission of Salmonella enterica Serovar Typhimurium Is Controlled by Virulence Factors and Indigenous Intestinal Microbiota (PDF) Questions on Lawley et al. (Word Doc; also available as a PDF)
	Sept 25	Literature Critique Due

5	Sept 30	Neisseria	Dillard
	Oct 2	Discussion A chromosomally integrated bacteriophage in invasive meningococci (PDF) Loss of both Holliday junction processing pathways is synthetically lethal in the presence of gonococcal pilin antigenic variation (PDF) Neisseria Discussion Questions (Word Doc; also available as a PDF)

6	Oct 7	Peptidoglycan	Dillard
	Oct 9	Discussion A New Family of Lysozyme Inhibitors Contributing to Lysozyme Tolerance in Gram-Negative Bacteria (PDF) Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island (PDF) Peptidoglycan Questions (Word Doc; also available as a PDF)

7	Oct 14	No class
	Oct 16	No class

8	Oct 21	Clostridia (Jared & Keith)
	Oct 23	Borrelia (Melanie & Valarie)

9	Oct 28	Burkholderia (Kelsea & Sarah)
	Oct 30	Rickettsia (Joe & Josh)

10	Nov 4	Vibrio	Ruby
	Nov 6	Discussion The Extracellular Nuclease Dns and Its Role in Natural Transformation of Vibrio cholerae (PDF) Vibrio Pathogenesis Questions (Word Doc; also available as a PDF)

11	Nov 11	Pasturella Powerpoint (PDF)	Czuprynski
	Nov 13	Discussion Characterization and Comparison of Biofilm Development by Pathogenic and Commensal Isolates of Histophilus somni (PDF) Expression of a modified Mannheimia haemolytica GS60 outer membrane lipoprotein in transgenic alfalfa for the development of an edible vaccine against bovine pneumonic pasteurellosis (PDF) Questions (Word Doc; also available as a PDF)

12	Nov 18	Erwinia	Charkowski
	Nov 20	Discussion Microarray profiling of host-extract-induced genes and characterization of the type VI secretion cluster in the potato pathogen Pectobacterium atrosepticum (PDF)
	Nov 21	Grant Proposals Due - 4:00 pm

13	Nov 25	No class
	Nov 27	Holiday

14	Dec 2	Brucella	Rambow-Larsen
	Dec 4	Discussion Brucella Evades Macrophage Killing via VirB-dependent Sustained Interactions with the Endoplasmic Reticulum (PDF) Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion system (PDF)

15	Dec 9	MMI Study Section
	Dec 9	Grant Critiques Due
	Dec 11	MMI Study Section

Grants Folder